EX-527 R-enantiomer

• CAT Number: I005081
• CAS Number: 848193-69-1
• Molecular Formula: C13H13ClN2O
• Molecular Weight: 248.71
• Purity: ≥95%
• Synonyms: (R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• Target: Sirtuin
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: [1]
• IUPAC Name: (1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• InChI: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)/t9-/m1/s1
• InChIKey: FUZYTVDVLBBXDL-SECBINFHSA-N
• SMILES: C1C[C@H](C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

The EX-527 R-enantiomer (Cat.No:I005081) is a selective inhibitor of the enzyme sirtuin 1 (SIRT1). SIRT1 plays a crucial role in various biological processes, including metabolism, aging, and stress response. The EX-527 R-enantiomer is commonly used in research to study the functions and potential therapeutic applications of SIRT1 inhibition.

Reference

[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

[2]. Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38.