Exatecan-amide-cyclopropanol

• CAT Number: I043344
• CAS Number: 2414254-34-3
• Molecular Formula: C28H26FN3O6
• Molecular Weight: 519.52
• Purity: ≥95%
• Synonyms: N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]-1-hydroxycyclopropane-1-carboxamide
• InChI: InChI=1S/C28H26FN3O6/c1-3-28(37)16-8-20-23-14(10-32(20)24(33)15(16)11-38-26(28)35)22-18(31-25(34)27(36)6-7-27)5-4-13-12(2)17(29)9-19(30-23)21(13)22/h8-9,18,36-37H,3-7,10-11H2,1-2H3,(H,31,34)/t18-,28-/m0/s1
• InChIKey: YBPWXIPEPLZSMS-JMQGSBJISA-N
• SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)C7(CC7)O)O

Exatecan-amide-cyclopropanol（Cat No.:I043344）is a novel compound under investigation for its potential in cancer treatment, particularly targeting tumors resistant to conventional therapies. It combines exatecan, a potent topoisomerase I inhibitor, with an amide and cyclopropanol structure, aiming to enhance anticancer efficacy by increasing its stability and bioavailability. This unique structure aims to overcome drug resistance mechanisms in cancer cells, providing an innovative approach in oncology. Researchers are exploring its therapeutic potential for various malignancies, including those that are difficult to treat with existing chemotherapy agents.