For research use only. Not for therapeutic Use.
Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).
| Catalog Number | I040669 |
| CAS Number | 143655-70-3 |
| Synonyms | N-(8-acetamido-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide |
| Molecular Formula | C15H17FN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H17FN2O3/c1-7-10-4-5-12(17-8(2)19)15(21)14(10)13(6-11(7)16)18-9(3)20/h6,12H,4-5H2,1-3H3,(H,17,19)(H,18,20) |
| InChIKey | UNQLSBJKEGXCGH-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C2=C1CCC(C2=O)NC(=O)C)NC(=O)C)F |
| Reference | [1]. Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10. [2]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. |
