Exatecan mesylate

• CAT Number: I002214
• CAS Number: 169869-90-3
• Molecular Formula: C25H26FN3O7S
• Molecular Weight: 531.55
• Purity: ≥95%
• Synonyms: DX 8951; DX-8951; DX8951.;(1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3/’,4/’:6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonic acid
• Target: Cell Cycle/DNA Damage
• Solubility: DMSO: ≤ 15.3 mg/mL
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: (10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid
• InChI: InChI=1S/C24H22FN3O4.CH4O3S/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19;1-5(2,3)4/h6-7,16,31H,3-5,8-9,26H2,1-2H3;1H3,(H,2,3,4)/t16-,24-;/m0./s1
• InChIKey: BICYDYDJHSBMFS-GRGFAMGGSA-N
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O.CS(=O)(=O)O

Exatecan Mesylate（Cat No.:I002214）is a potent topoisomerase I inhibitor, designed to disrupt DNA replication in cancer cells, leading to cell death. It is an active component of antibody-drug conjugates (ADCs), specifically engineered for targeted cancer therapy. By binding to a monoclonal antibody, Exatecan Mesylate delivers its cytotoxic effect directly to tumor cells, minimizing damage to healthy tissues. This approach enhances the efficacy and safety of cancer treatment, making Exatecan Mesylate a valuable agent in the development of advanced therapies for various malignancies, including solid tumors and hematologic cancers.