exo BCN-O-PNB

• CAT Number: I016258
• CAS Number: 1380006-72-3
• Molecular Formula: C₁₇H₁₇NO₅
• Molecular Weight: 315.32
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: [(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C17H17NO5/c19-17(23-13-9-7-12(8-10-13)18(20)21)22-11-16-14-5-3-1-2-4-6-15(14)16/h7-10,14-16H,3-6,11H2/t14-,15+,16?
• InChIKey: QXNXOXMDBLHIDB-XYPWUTKMSA-N
• SMILES: C1C[C@@H]2[C@@H](C2COC(=O)OC3=CC=C(C=C3)[N+](=O)[O-])CCC#C1

Exo BCN-O-PNB（Cat No.:I016258）is a bioorthogonal chemical compound used in click chemistry, specifically in chemical labeling and conjugation applications. It contains a BCN (bicyclononynyl) group, which is reactive with azides in copper-free click reactions, allowing for selective and efficient conjugation with biomolecules. The PNB (p-nitrobenzyl) group in Exo BCN-O-PNB acts as a photocleavable moiety, enabling spatial and temporal control of the conjugation reaction upon exposure to light. This compound is widely used in molecular biology and drug delivery systems for labeling proteins, peptides, and other biomolecules in research and therapeutic applications.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.