exo BCN-O-PNB

• CAT Number: I016258
• CAS Number: 1380006-72-3
• Molecular Formula: C₁₇H₁₇NO₅
• Molecular Weight: 315.32
• Purity: ≥95%
• Target: PROTAC Linkers

exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.