For research use only. Not for therapeutic Use.
Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC<sub>50</sub> = 20 µM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus.
| Catalog Number | R065796 |
| CAS Number | 75541-83-2 |
| Synonyms | Exocytic Inhibitor 1;NSC 214045 |
| Molecular Formula | C15H12FNO3 |
| Purity | ≥95% |
| Storage | Room temperature |
| IUPAC Name | methyl 2-[(4-fluorobenzoyl)amino]benzoate |
| InChI | InChI=1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18) |
| InChIKey | KIAPWMKFHIKQOZ-UHFFFAOYSA-N |
| SMILES | COC(=O)C1=CC=CC=C1NC(=O)C2=CC=C(C=C2)F |
| Reference | 1.Feng, Y.,Yu, S.,Lasell, T.K.R., et al. Exo1: A new chemical inhibitor of the exocytic pathway. Proceedings of the National Academy of Sciences of the United States of America 100(11), 6469-6474 (2003). |
