(E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen 2’-Azide

• CAT Number: R049734
• CAS Number: 1331643-32-3
• Molecular Formula: C24H23N3O2
• Molecular Weight: 385.467
• Purity: ≥95%
• Synonyms: 4-[1-[4-(2-Azidoethoxy)phenyl]-2-phenyl-1-buten-1-yl]phenol
• Storage: Store at RT
• IUPAC Name: 4-[(Z)-1-[4-(2-azidoethoxy)phenyl]-2-phenylbut-1-enyl]phenol
• InChI: InChI=1S/C24H23N3O2/c1-2-23(18-6-4-3-5-7-18)24(19-8-12-21(28)13-9-19)20-10-14-22(15-11-20)29-17-16-26-27-25/h3-15,28H,2,16-17H2,1H3/b24-23-
• InChIKey: BCHPNTIJLIFVLF-VHXPQNKSSA-N
• SMILES: CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN=[N+]=[N-])C3=CC=CC=C3

(E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen 2’-Azide is a modified derivative of tamoxifen, a well-known selective estrogen receptor modulator (SERM) used in breast cancer therapy. This compound features both (E/Z) isomeric forms and includes an azide functional group, which is often used in bioconjugation reactions, particularly in click chemistry. The removal of methyl groups (didesmethyl) and the hydroxylation at the 4-position enhance its biological activity and binding affinity to estrogen receptors. (E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen 2’-Azide is of particular interest in cancer research for studying the mechanisms of tamoxifen’s action and developing novel therapeutic strategies, including targeted drug delivery systems.