F16

• CAT Number: I003324
• CAS Number: 36098-33-6
• Molecular Formula: C16H15N2 • I
• Molecular Weight: 362.21
• Purity: ≥95%
• Synonyms: 4-[(1E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-pyridinium iodide
• Target: Apoptosis
• Solubility: DMSO ≥ 31 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 3-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole;iodide
• InChI: InChI=1S/C16H14N2.HI/c1-18-10-8-13(9-11-18)6-7-14-12-17-16-5-3-2-4-15(14)16;/h2-12H,1H3;1H
• InChIKey: UURAKYSOOXPORG-UHFFFAOYSA-N
• SMILES: C[N+]1=CC=C(C=C1)/C=C/C2=CNC3=CC=CC=C32.[I-]

F16 (Cat.No:I003324) is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines.

Reference

[1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42.

[2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36.