F16

• CAT Number: I003324
• CAS Number: 36098-33-6
• Molecular Formula: C16H15N2 • I
• Molecular Weight: 362.21
• Purity: ≥95%
• Synonyms: 4-[(1E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-pyridinium iodide
• Target: Apoptosis
• Solubility: DMSO ≥ 31 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 3-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole;iodide
• InChI: InChI=1S/C16H14N2.HI/c1-18-10-8-13(9-11-18)6-7-14-12-17-16-5-3-2-4-15(14)16;/h2-12H,1H3;1H
• InChIKey: UURAKYSOOXPORG-UHFFFAOYSA-N
• SMILES: C[N+]1=CC=C(C=C1)/C=C/C2=CNC3=CC=CC=C32.[I-]

F16 (Cat.No:I003324) is a small molecule peptide that targets the cell surface protein integrin αvβ6, which is overexpressed in various cancer cells, particularly in epithelial cancers. By binding to αvβ6, F16 selectively delivers therapeutic agents or imaging agents to tumor cells, offering potential for targeted cancer treatment and diagnosis. It has shown promise in preclinical studies as a tool for both drug delivery and cancer imaging, with applications in precision medicine. Research continues to evaluate its clinical efficacy and safety.

 

Reference

[1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42.

[2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36.