FAAH inhibitor 1

• CAT Number: I003155
• CAS Number: 326866-17-5
• Molecular Formula: C24H23N3O3S3
• Molecular Weight: 497.65
• Purity: ≥95%
• Synonyms: N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-1-thiophen-2-ylsulfonylpiperidine-4-carboxamide
• Target: FAAH
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 18±8 nM

FAAH Inhibitor 1（Cat No.:I003155）is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), an enzyme crucial in the breakdown of endocannabinoids, such as anandamide. By inhibiting FAAH, this compound increases endocannabinoid levels, enhancing their signaling, which plays a significant role in pain modulation, mood regulation, and inflammation. FAAH Inhibitor 1 holds promise in pain management and neuroinflammation research, as well as potential therapeutic applications for mood disorders and chronic pain. Its high selectivity ensures targeted action with minimized off-target effects, making it valuable for further pharmacological exploration.

Reference

[1]. Wang, Xueqing; Sarris, Katerina; Kage, Karen; et al. Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors. Journal of Medicinal Chemistry (2009), 52(1), 170-180.
[2]. Meyers, Marvin J.; Long, Scott A.; Pelc, Matthew J.; et al. Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds. Bioorganic & Medicinal Chemistry Letters (2011), 21(21), 6538-6544.