Famciclovir

For research use only, not for therapeutic use.

  • CAT Number: A000218
  • CAS Number: 104227-87-4
  • Molecular Formula: C14H19N5O4
  • Molecular Weight: 321.33
  • Purity: ≥95%
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Famciclovir (INN) is a guanosine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is also indicated for treatment of recurrent episodes of herpes simplex in HIV patients. It is a prodrug form of penciclovir with improved oral bioavailability.


Catalog Number A000218
CAS Number 104227-87-4
Synonyms

104227-87-4; Famvir; Famciclovirum; 2-(2-(2-Amino-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate; BRL-42810

Molecular Formula C14H19N5O4
Purity ≥95%
Target HSV
Solubility >8.8mg/mL in DMSO
Storage -20°C
InChI 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
InChIKey GGXKWVWZWMLJEH-UHFFFAOYSA-N
SMILES CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
Reference

1: Kim SH, Yeo SG. Response to Letter to the Editor: /Comparison of Acyclovir and
Famciclovir for Ramsay Hunt Syndrome/. Otol Neurotol. 2017 Oct 23. doi:
10.1097/MAO.0000000000001607. [Epub ahead of print] PubMed PMID: 29065091.
<br>

2: Patel CV, Kishore K. Concomitant Intravitreal Ganciclovir and Dexamethasone
Therapy in the Management of Acute Retinal Necrosis in a Patient Previously
Treated with Oral Famciclovir. Case Rep Ophthalmol Med. 2017;2017:4613624. doi:
10.1155/2017/4613624. Epub 2017 Aug 8. PubMed PMID: 28932612; PubMed Central
PMCID: PMC5591910.
<br>

3: Pridgen WL, Duffy C, Gendreau JF, Gendreau RM. A famciclovir + celecoxib
combination treatment is safe and efficacious in the treatment of fibromyalgia. J
Pain Res. 2017 Feb 22;10:451-460. doi: 10.2147/JPR.S127288. eCollection 2017.
PubMed PMID: 28260944; PubMed Central PMCID: PMC5328426.
<br>

4: Kim HJ, Jung J, Kim SS, Byun JY, Park MS, Yeo SG. Comparison of Acyclovir and
Famciclovir for Ramsay Hunt Syndrome. Otol Neurotol. 2017 Jun;38(5):754-758. doi:
10.1097/MAO.0000000000001367. PubMed PMID: 28221283.
<br>

5: Polansky H, Javaherian A, Itzkovitz E. Clinical study in genital herpes:
natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir.
Drug Des Devel Ther. 2016 Aug 29;10:2713-22. doi: 10.2147/DDDT.S112852.
eCollection 2016. PubMed PMID: 27621592; PubMed Central PMCID: PMC5010074.
<br>

6: Thomasy SM, Shull O, Outerbridge CA, Lim CC, Freeman KS, Strom AR, Kass PH,
Maggs DJ. Oral administration of famciclovir for treatment of spontaneous ocular,
respiratory, or dermatologic disease attributed to feline herpesvirus type 1: 59
cases (2006-2013). J Am Vet Med Assoc. 2016 Sep 1;249(5):526-38. doi:
10.2460/javma.249.5.526. PubMed PMID: 27556267.

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7: Kim HJ, Kim SH, Jung J, Kim SS, Byun JY, Park MS, Yeo SG. Erratum to:
Comparison of acyclovir and famciclovir for the treatment of Bell/’s palsy. Eur
Arch Otorhinolaryngol. 2016 Oct;273(10):3091-3092. PubMed PMID: 27501992.
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8: Sebbag L, Thomasy SM, Woodward AP, Knych HK, Maggs DJ. Pharmacokinetic
modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to
optimize dosage recommendations for oral administration of famciclovir. Am J Vet
Res. 2016 Aug;77(8):833-45. doi: 10.2460/ajvr.77.8.833. PubMed PMID: 27463546.
<br>

9: Kim HJ, Kim SH, Jung J, Kim SS, Byun JY, Park MS, Yeo SG. Comparison of
acyclovir and famciclovir for the treatment of Bell/’s palsy. Eur Arch
Otorhinolaryngol. 2016 Oct;273(10):3083-90. doi: 10.1007/s00405-016-3927-3. Epub
2016 Feb 12. Erratum in: Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3091-2.
PubMed PMID: 26873601.
<br>

10: Yaldiz M, Solak B, Kara RO, Cosansu N, Erdem MT. Comparison of Famciclovir,
Valaciclovir, and Brivudine Treatments in Adult Immunocompetent Patients With
Herpes Zoster. Am J Ther. 2016 Jan 20. [Epub ahead of print] PubMed PMID:
26808358.

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