FAPy-adenine

• CAT Number: I017240
• CAS Number: 5122-36-1
• Molecular Formula: C5H7N5O
• Molecular Weight: 153.14
• Purity: ≥95%
• Synonyms: N-(4,6-diaminopyrimidin-5-yl)formamide
• InChI: InChI=1S/C5H7N5O/c6-4-3(10-2-11)5(7)9-1-8-4/h1-2H,(H,10,11)(H4,6,7,8,9)
• InChIKey: MVYUVUOSXNYQLL-UHFFFAOYSA-N
• SMILES: C1=NC(=C(C(=N1)N)NC=O)N

FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer’s disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].
In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine[1].
The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer’s disease and support the concept that the brain is under increased oxidative stress in Alzheimer’s disease[1].

Reference

[1]. Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer’s disease.
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[2]. Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45.
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[3]. Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7.
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