Fargesin

• CAT Number: I014377
• CAS Number: 31008-19-2
• Molecular Formula: C21H22O6
• Molecular Weight: 370.401
• Purity: ≥95%
• Synonyms: Fargesin;1H,3H-Furo(3,4-C)furan, 1alpha-(3,4-dimethoxyphenyl)-3abeta,4,6,6abeta-tetrahydro-4beta-((3,4-methylenedioxy)phenyl)-
• Target: AP-1
• Solubility: Soluble in DMSO
• InChI: InChI=1S/C21H22O6/c1-22-16-5-3-12(7-18(16)23-2)20-14-9-25-21(15(14)10-24-20)13-4-6-17-19(8-13)27-11-26-17/h3-8,14-15,20-21H,9-11H2,1-2H3/t14?,15?,20-,21+/m0/s1
• InChIKey: AWOGQCSIVCQXBT-USWJAIAZSA-N
• SMILES: COC1=CC=C([C@@H]2OCC3C2CO[C@@H]3C4=CC(OCO5)=C5C=C4)C=C1OC

Fargesin(CAT: I014377) is a lignan derived from Magnolia fargesii, an oriental medicinal plant employed for addressing nasal congestion and sinusitis. This compound demonstrates anti-inflammatory effects on THP-1 cells by inhibiting the PKC pathway, thereby suppressing downstream factors such as JNK, nuclear factors AP-1, and NF-ĸB. Additionally, Fargesin reveals potential as a β₁ adrenergic receptor antagonist, offering heart protection against ischemia/reperfusion injury in rats. Its mechanism involves mitigating oxidative stress and apoptosis. Fargesin’s diverse effects, from combating inflammation to potential cardiac benefits, highlight its significance in traditional medicine and its potential for broader therapeutic applications.

Reference

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