FAS Inhibitor, C75

• CAT Number: I002453
• CAS Number: 191282-48-1
• Molecular Formula: C₁₄H₂₂O₄
• Molecular Weight: 254.30
• Purity: ≥95%
• Synonyms: trans-C75; 4-methylidene-2-octyl-5-oxooxolane-3-carboxylic acid
• Target: Fatty Acid Synthase (FASN)
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IC50: 35.4 μM(LNCaP cel)
• IUPAC Name: (2R,3S)-4-methylidene-2-octyl-5-oxooxolane-3-carboxylic acid
• InChI: InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
• InChIKey: VCWLZDVWHQVAJU-NEPJUHHUSA-N
• SMILES: CCCCCCCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O

C75 trans (Cat No.:I002453) is a powerful synthetic inhibitor of fatty acid synthase (FAS/FASN). It exhibits IC50 values of 35 μM and 50 μM in adult plant assay and spheroid growth assay, respectively. C75 is a valuable tool for investigating fatty acid synthesis in metabolic disorders and cancer. It offers insights into the molecular mechanisms underlying these conditions and can be utilized in research and drug development targeting aberrant fatty acid synthesis pathways. C75’s potent inhibitory properties make it an important compound for studying and potentially addressing metabolic and cancer-related abnormalities.

Reference

[1]. Sadowski MC, et al. The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget. 2014 Oct 15;5(19):9362-81.
[2]. Impheng H, et al. The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. PLoS One. 2014 Sep 25;9(9):e107842.
[3]. Chen C, et al. 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem. 2014 Jun 13;289(24):17184-94.
[4]. Matsuo S, et al. Fatty acid synthase inhibitor C75 ameliorates experimental colitis. Mol Med. 2014 Jan 17;20:1-9.