For research use only. Not for therapeutic Use.
Fasitibant (Cat No.: I027286) is a selective, competitive bradykinin B2 receptor antagonist that inhibits the effects of bradykinin, a key mediator in inflammation and pain. It has been studied for its potential therapeutic applications in inflammatory and autoimmune diseases, including hereditary angioedema and osteoarthritis. By blocking B2 receptor activation, Fasitibant helps reduce vasodilation, vascular permeability, and pain signaling. Its role in modulating the kallikrein-kinin system makes it a promising candidate for conditions involving excessive inflammation and vascular dysfunction.
| CAS Number | 869939-83-3 |
| Synonyms | Fasitibant |
| Molecular Formula | C36H49Cl2N6O6S |
| Purity | 98% |
| Target | Bradykinin Receptor |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-4-amino-5-(4-(4-((2,4-dichloro-3-(((2,4-dimethylquinolin-8-yl)oxy)methyl)phenyl)sulfonamido)tetrahydro-2H-pyran-4-carbonyl)piperazin-1-yl)-N,N,N-trimethyl-5-oxopentan-1-aminium |
| InChI | InChI=1S/C36H49Cl2N6O6S/c1-24-22-25(2)40-33-26(24)8-6-10-30(33)50-23-27-28(37)11-12-31(32(27)38)51(47,48)41-36(13-20-49-21-14-36)35(46)43-17-15-42(16-18-43)34(45)29(39)9-7-19-44(3,4)5/h6,8,10-12,22,29,41H,7,9,13-21,23,39H2,1-5H3/q+1/t29-/m0/s1 |
| InChIKey | FQVSDHOWSLEEKJ-LJAQVGFWSA-N |
| SMILES | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC4(CCOCC4)C(=O)N5CCN(CC5)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
