Fasudil, Monohydrochloride

  • CAT Number: A000787
  • CAS Number: 105628-07-7
  • Molecular Formula: C₁₄H₁₇N₃O₂S•HCl
  • Molecular Weight: 327.83
  • Purity: ≥95%
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Fasudil monohydrochloride(Cat No.:A000787)is a potent Rho kinase inhibitor, primarily used to improve cerebral blood flow and reduce vascular resistance in conditions like vasospasm after subarachnoid hemorrhage. By inhibiting Rho kinase, fasudil promotes vasodilation and enhances endothelial function, making it beneficial in treating ischemic conditions. It has also shown promise in other therapeutic areas, including cardiovascular diseases and neurodegenerative disorders. Administered orally or intravenously, fasudil’s favorable safety profile and efficacy in enhancing cerebral perfusion position it as a valuable option in neuroprotective therapies and vascular management.


Catalog Number A000787
CAS Number 105628-07-7
Synonyms

NA

Molecular Formula C₁₄H₁₇N₃O₂S•HCl
Purity ≥95%
Target ROCK
Solubility >16.4mg/mL in DMSO
Storage 3 years -20C powder
IUPAC Name 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
InChI InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChIKey LFVPBERIVUNMGV-UHFFFAOYSA-N
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

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