For research use only. Not for therapeutic Use.
Fatostatin A (CAT: I001001) is a small molecule inhibitor that specifically targets the enzyme SREBP (sterol regulatory element-binding protein) cleavage-activating protein (SCAP). SCAP is essential for the activation of SREBP, a key transcription factor involved in the regulation of cholesterol and lipid metabolism. By inhibiting SCAP, Fatostatin A disrupts the processing and nuclear translocation of SREBP, thereby reducing the expression of SREBP target genes involved in cholesterol and fatty acid synthesis. This pharmacological activity makes Fatostatin A a valuable tool in studying lipid metabolism and a potential candidate for the development of therapies targeting dyslipidemia and related metabolic disorders.
Catalog Number | I001001 |
CAS Number | 125256-00-0 |
Molecular Formula | C18H18N2S |
Purity | ≥95% |
Target | Fatty Acid Synthase (FASN) |
Solubility | DMSO ≥ 27 mg/mL |
Storage | Store at -20°C |
Reference | <p style=/line-height:25px/> <br>[2]. Shao W et al. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res. 2016 Aug;57(8):1564-73. <br>[3]. Inoue K et al. Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation. Biochim Biophys Acta. 2015 Nov;1852(11):2432-41. </p> |