FATP1-IN-2

• CAT Number: I045246
• CAS Number: 2650944-83-3
• Molecular Formula: C19H20FN5O
• Molecular Weight: 353.39
• Purity: ≥95%
• Synonyms: 2-[4-(5-fluoropyridin-2-yl)piperazin-1-yl]-1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone
• InChI: InChI=1S/C19H20FN5O/c1-14-19(25-7-3-2-4-18(25)22-14)16(26)13-23-8-10-24(11-9-23)17-6-5-15(20)12-21-17/h2-7,12H,8-11,13H2,1H3
• InChIKey: ZGLMIQGBDRQCKA-UHFFFAOYSA-N
• SMILES: CC1=C(N2C=CC=CC2=N1)C(=O)CN3CCN(CC3)C4=NC=C(C=C4)F

FATP1-IN-2 (compound 12a), an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1].
FATP1-IN-2 (10 mg/kg; p.o.) shows a Cmax value above the mouse IC50 value[1].
FATP1-IN-2 (3, 10, 30 mg/kg; p.o.; 4 weeks) shows TG content of each tissue does not change at any dose[1].

Reference

[1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565.
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