For research use only. Not for therapeutic Use.
FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM)[1][2].
FAUC 346, an in vitro D3-selective ligand with a Ki of 0.23 nM in CHO cells for D3 receptor[1].
FAUC346 shows some affinity for 5HT1A receptors (Ki = 41 nM) and for α1 receptors (Ki = 15 nM)[1].
| Catalog Number | I044471 |
| CAS Number | 474432-65-0 |
| Synonyms | N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamide |
| Molecular Formula | C24H29N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C24H29N3O2S/c1-29-21-10-4-3-9-20(21)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-5-11-22(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28) |
| InChIKey | KFMBPIZMZUDONQ-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4S3 |
| Reference | [1]. Bertrand Kuhnast, et al. Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide — a potential radiotracer for D3 receptor imaging with PET. Nucl Med Biol. 2006 Aug;33(6):785-95. [2]. Carsten Hocke, et al. 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. ChemMedChem. 2008 May;3(5):788-93. |
