FAUC 365

For research use only. Not for therapeutic Use.

  • CAT Number: I011580
  • CAS Number: 474432-66-1
  • Molecular Formula: C23H25Cl2N3OS
  • Molecular Weight: 462.44
  • Purity: ≥95%
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FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson’s disease[1][2].


Catalog Number I011580
CAS Number 474432-66-1
Synonyms

N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamide

Molecular Formula C23H25Cl2N3OS
Purity ≥95%
InChI InChI=1S/C23H25Cl2N3OS/c24-18-7-5-8-19(22(18)25)28-14-12-27(13-15-28)11-4-3-10-26-23(29)21-16-17-6-1-2-9-20(17)30-21/h1-2,5-9,16H,3-4,10-15H2,(H,26,29)
InChIKey CPTSTFKVXWZGEV-UHFFFAOYSA-N
SMILES C1CN(CCN1CCCCNC(=O)C2=CC3=CC=CC=C3S2)C4=C(C(=CC=C4)Cl)Cl
Reference

[1]. Philip Seeman, et al. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse. 2006 Sep 1;60(3):205-11.
 [Content Brief]

[2]. Carsten Hocke, et al. Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3963-6.
 [Content Brief]

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