For research use only. Not for therapeutic Use.
Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research[1][2].
| Catalog Number | I041947 |
| CAS Number | 1808918-69-5 |
| Synonyms | [(1S,2R,5S)-2-[(5-fluoropyridin-2-yl)oxymethyl]-8-azabicyclo[3.2.1]octan-8-yl]-(5-methyl-2-pyrimidin-2-ylphenyl)methanone |
| Molecular Formula | C25H25FN4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H25FN4O2/c1-16-3-8-20(24-27-11-2-12-28-24)21(13-16)25(31)30-19-6-4-17(22(30)9-7-19)15-32-23-10-5-18(26)14-29-23/h2-3,5,8,10-14,17,19,22H,4,6-7,9,15H2,1H3/t17-,19-,22-/m0/s1 |
| InChIKey | PMJPLAGTPPVSRL-JLMWRMLUSA-N |
| SMILES | CC1=CC(=C(C=C1)C2=NC=CC=N2)C(=O)N3C4CCC(C3CC4)COC5=NC=C(C=C5)F |
| Reference | [1]. Zhang Y, et al. Asymmetric Synthesis of Nortropanes via Rh-Catalyzed Allylic Arylation. ACS Catal. 2022 Aug 5;12(15):8995-9002. [2]. Zhenya Zeng, et al. Development of a Scalable Route with Efficient Stereoisomer Control to YZJ-1139, an Orexin Receptor Antagonist. Org. Process Res. Dev. 2022, 26, 2, 447-457. |
