FB23-2

• CAT Number: I019008
• CAS Number: 2243736-45-8
• Molecular Formula: C₁₈H₁₅Cl₂N₃O₃
• Molecular Weight: 392.24
• Purity: ≥95%
• Target: Apoptosis
• Storage: under inert gas (nitrogen or Argon) at 2-8°C
• IUPAC Name: 2-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]-N-hydroxybenzamide
• InChI: InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
• InChIKey: ILHNIWOZZKIBNW-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)NO)Cl

FB23-2（Cat No.:I019008） is a highly potent and selective inhibitor of the fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A) demethylase enzyme. It exerts its inhibitory effect by directly binding to FTO and specifically inhibiting its m6A demethylase activity. With an IC50 value of 2.6 μM, FB23-2 displays strong potency in blocking the demethylation process. This compound holds significant potential for studying the biological roles of m6A modification and FTO function, and it may serve as a valuable tool in epigenetic and RNA-related research.

Reference

[1]. Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10.