For research use only. Not for therapeutic Use.
FC-11(CAT: I027304) is a potent PROTAC (proteolysis-targeting chimera) degrader of focal adhesion kinase (FAK), demonstrating remarkable efficacy across various cell lines with DC50 values ranging from 40 pM to 370 pM. It combines a CRBN ligand (Pomalidomide), a linker, and a FAK ligand (PF562271), inducing selective degradation of FAK, a key regulator of cell migration and survival in cancer. FC-11 has shown impressive degradation efficiency in TM3, PA1, MDA-MB-436, LNCaP, and Ramos cells, making it a promising tool in Cancer Disease Research for targeting FAK-mediated pathways in oncogenesis and metastasis.
| CAS Number | 2271035-37-9 |
| Synonyms | 1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[2-[methyl(methylsulfonyl)amino]pyridin-3-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]triazole-4-carboxamide |
| Molecular Formula | C41H42F3N13O9S |
| Purity | ≥95% |
| IUPAC Name | 1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[2-[methyl(methylsulfonyl)amino]pyridin-3-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]triazole-4-carboxamide |
| InChI | InChI=1S/C41H42F3N13O9S/c1-55(67(2,63)64)35-24(5-4-14-46-35)21-47-34-28(41(42,43)44)22-48-40(52-34)50-26-10-8-25(9-11-26)49-36(59)30-23-56(54-53-30)16-18-66-20-19-65-17-15-45-29-7-3-6-27-33(29)39(62)57(38(27)61)31-12-13-32(58)51-37(31)60/h3-11,14,22-23,31,45H,12-13,15-21H2,1-2H3,(H,49,59)(H,51,58,60)(H2,47,48,50,52) |
| InChIKey | RZKZQCHSKWKOAJ-UHFFFAOYSA-N |
| SMILES | CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3)NC(=O)C4=CN(N=N4)CCOCCOCCNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)S(=O)(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
