For research use only. Not for therapeutic Use.
Inhibitor of TLR3 expression and inflammatory responses induced by a synthetic dsRNA (poly(I:C)) and by exogenous IFN-α via IRF3. FC-99 suppressed the phosphorylation levels of ERK, JNK, and p38 in varying degrees without altering the total protein The ability of FC-99 to reverse TLR3 expression may account for its marked effect on the model of sepsis.
| Catalog Number | I047606 |
| CAS Number | 2734014-73-2 |
| Molecular Formula | C15H18N2O.HCl |
| Purity | ≥95% |
| IUPAC Name | 1-N-[(4-methoxyphenyl)methyl]-4-methylbenzene-1,2-diamine;hydrochloride |
| InChI | InChI=1S/C15H18N2O.ClH/c1-11-3-8-15(14(16)9-11)17-10-12-4-6-13(18-2)7-5-12;/h3-9,17H,10,16H2,1-2H3;1H |
| SMILES | CC1=CC(=C(C=C1)NCC2=CC=C(C=C2)OC)N.Cl |
| Reference | W. Gong et al. A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis. Br. J. Pharmacol. 2014, 171, 4866-4878. |
