FCE-24379

• CAT Number: I027331
• CAS Number: 113869-44-6
• Molecular Formula: C20H22N4O2
• Molecular Weight: 350.42
• Purity: 98%
• Synonyms: FCE-24379; FCE24379; FCE 24379
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2,4(1H,3H)-Pyrimidinedione, dihydro-1-((2,7,8,9,9a,10-hexahydro-9-methylpyrrolo(3',2':5,6)cyclohept(1,2,3-cd)indol-7-yl)methyl)-, (7R-cis)-
• InChI: InChI=1S/C20H22N4O2/c1-23-10-14(11-24-6-5-18(25)22-20(24)26)15-7-12-3-2-4-16-19(12)13(9-21-16)8-17(15)23/h2-4,7,9,14,17,21H,5-6,8,10-11H2,1H3,(H,22,25,26)/t14-,17-/m1/s1
• InChIKey: OJPZLSMBNYRZIW-RHSMWYFYSA-N
• SMILES: CN1C[C@H](CN2CCC(=O)NC2=O)C3=Cc4cccc5[nH]cc(C[C@@H]13)c45

FCE-24379 (Cat No.: I027331)is a potent and selective inhibitor of topoisomerase I, an essential enzyme involved in DNA replication and transcription. It belongs to the class of camptothecin derivatives and exhibits strong antitumor activity by stabilizing the topoisomerase I-DNA complex, leading to DNA damage and apoptosis in rapidly dividing cancer cells. FCE-24379 has shown promise in preclinical cancer models, particularly against solid tumors. It is used in oncology research to explore novel chemotherapeutic strategies targeting DNA replication and repair mechanisms.

Reference

1. Salvati P, Vaghi F, Colombo M, Bianchi G. A new selective antagonist of vascular serotonin receptors lowers blood pressure in spontaneously hypertensive rats. Drugs. 1988;36 Suppl 1:105-9. doi: 10.2165/00003495-198800361-00019. PMID: 3240722.