For research use only. Not for therapeutic Use.
Febantel（Cat No.:I004174）is a broad-spectrum anthelmintic widely used in veterinary medicine to treat gastrointestinal parasitic infections in animals. It is a prodrug that metabolizes into fenbendazole and oxfendazole, compounds that inhibit tubulin polymerization, disrupting the microtubule-dependent energy metabolism in parasites. Effective against nematodes, cestodes, and some protozoa, febantel is often combined with other anthelmintics, such as praziquantel or pyrantel, for enhanced efficacy. It is commonly administered in oral formulations and is well-tolerated by various species. Febantel is a reliable choice for maintaining animal health and controlling parasitic infestations.
| Catalog Number | I004174 |
| CAS Number | 58306-30-2 |
| Molecular Formula | C20H22N4O6S |
| Purity | ≥95% |
| Target | Parasite |
| Solubility | Soluble in acetone(> 10 mM) |
| Storage | 3 years -20C powder |
| IUPAC Name | methyl N-[N'-[2-[(2-methoxyacetyl)amino]-4-phenylsulfanylphenyl]-N-methoxycarbonylcarbamimidoyl]carbamate |
| InChI | InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27) |
| InChIKey | HMCCXLBXIJMERM-UHFFFAOYSA-N |
| SMILES | COCC(=O)NC1=C(C=CC(=C1)SC2=CC=CC=C2)N=C(NC(=O)OC)NC(=O)OC |
| Reference | </br>1:Simultaneous determination of praziquantel, pyrantel embonate, febantel and its active metabolites, oxfendazole and fenbendazole, in dog plasma by liquid chromatography/mass spectrometry. Klausz G, Keller É, Sára Z, Székely-Körmöczy P, Laczay P, Ary K, Sótonyi P, Róna K.Biomed Chromatogr. 2015 Dec;29(12):1859-65. doi: 10.1002/bmc.3507. Epub 2015 Jun 24. PMID: 26104502 </br>2:Chemometric quality inspection control of pyrantel pamoate, febantel and praziquantel in veterinary tablets by mid infrared spectroscopy. Piantavini MS, Pontes FL, Uber CP, Stremel DP, Sena MM, Pontarolo R.Spectrochim Acta A Mol Biomol Spectrosc. 2014 May 5;125:396-403. doi: 10.1016/j.saa.2014.01.078. Epub 2014 Jan 24. PMID: 24566119 </br>3:Formulation of poorly water-soluble drugs via coacervation–a pilot study using febantel. De Jaeghere W, De Geest BG, Van Bocxlaer J, Remon JP, Vervaet C, Antunes da Fonseca A.Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):930-5. doi: 10.1016/j.ejpb.2013.07.006. Epub 2013 Jul 18. PMID: 23872178 </br>4:Efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs. Taweethavonsawat P, Chungpivat S, Satranarakun P, Traub RJ, Schaper R.Parasitol Res. 2010 Jan;106(2):533-7. doi: 10.1007/s00436-009-1665-9. Epub 2009 Nov 13. PMID: 19911198 </br>5:Synergistic effect of febantel and pyrantel embonate in elimination of Giardia in a gerbil model. Olson ME, Heine J.Parasitol Res. 2009 Aug;105 Suppl 1:S135-40. doi: 10.1007/s00436-009-1504-z. PMID: 19575234 </br>6:Efficacy of Drontal Flavour Plus (50 mg praziquantel, 144 mg pyrantel embonate, 150 mg febantel per tablet) against Giardia sp in naturally infected dogs. Montoya A, Dado D, Mateo M, Espinosa C, Miró G.Parasitol Res. 2008 Oct;103(5):1141-4. doi: 10.1007/s00436-008-1107-0. Epub 2008 Jul 26. PMID: 18661153 </br>7:Comparative effects of milbemycin oxime-based and febantel-pyrantel embonate-based anthelmintic tablets on Toxocara canis egg shedding in naturally infected pups. Schenker R, Cody R, Strehlau G, Alexander D, Junquera P.Vet Parasitol. 2006 Apr 30;137(3-4):369-73. Epub 2006 Feb 21. PMID: 16490320 </br>8:Efficacy of a combination of febantel, pyrantel, and praziquantel for the treatment of kittens experimentally infected with Giardia species. Scorza AV, Radecki SV, Lappin MR.J Feline Med Surg. 2006 Feb;8(1):7-13. Epub 2005 Jul 11. PMID: 16011902 </br>9:Rapid determination of the antiparasitic drugs flubendazole and febantel in feeds by HPLC with ultraviolet detection. Dusi G, Gamba V, Faggionato E.J Pharm Biomed Anal. 2005 Jun 15;38(2):375-9. Epub 2005 Feb 16. PMID: 15925235 </br>10:Comparative efficacy of flubendazole chewable tablets and a tablet combination of febantel, pyrantel embonate and praziquantel against Trichuris vulpis in experimentally infected dogs. Prelezov PN, Bauer C.Dtsch Tierarztl Wochenschr. 2003 Oct;110(10):419-21. PMID: 14650738 |
