For research use only. Not for therapeutic Use.
Fedovapagon, also known as VA106483 and VT483, is a potent, nonpeptidic vasopressin V2 receptor agonist. Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney.
| CAS Number | 347887-36-9 |
| Synonyms | (2S)-N2,N2-Dimethyl-N1-[[2-methyl-4-[(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl]methyl]-1,2-pyrrolidinedicarboxamide; (S)-N2,N2-Dimethyl-N1-(2-methyl-4-(2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)benzyl)pyrrolidine-1,2-dicarboxami |
| Molecular Formula | C27H34N4O3 |
| Purity | ≥95% |
| Target | Vasopressin Receptor |
| Storage | Store at RT |
| IUPAC Name | (2S)-2-N,2-N-dimethyl-1-N-[[2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]methyl]pyrrolidine-1,2-dicarboxamide |
| InChI | InChI=1S/C27H34N4O3/c1-19-17-21(25(32)30-15-7-6-10-20-9-4-5-11-23(20)30)13-14-22(19)18-28-27(34)31-16-8-12-24(31)26(33)29(2)3/h4-5,9,11,13-14,17,24H,6-8,10,12,15-16,18H2,1-3H3,(H,28,34)/t24-/m0/s1 |
| InChIKey | RUOLFWZIFNQQGH-DEOSSOPVSA-N |
| SMILES | CC1=C(C=CC(=C1)C(=O)N2CCCCC3=CC=CC=C32)CNC(=O)N4CCCC4C(=O)N(C)C |
| Reference | </br>1: Yea CM, Allan CE, Ashworth DM, Barnett J, Baxter AJ, Broadbridge JD, Franklin </br> RJ, Hampton SL, Hudson P, Horton JA, Jenkins PD, Penson AM, Pitt GR, Rivière P,</br> Robson PA, Rooker DP, Semple G, Sheppard A, Haigh RM, Roe MB. New benzylureas as </br> a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med</br> Chem. 2008 Dec 25;51(24):8124-34. doi: 10.1021/jm8008162. PubMed PMID: 19053774.</br></br> |
