Felbamate

• CAT Number: A000408
• CAS Number: 25451-15-4
• Molecular Formula: C11H14N2O4
• Molecular Weight: 238.2
• Purity: ≥95%
• Synonyms: 25451-15-4; Felbatol; 2-Phenylpropane-1,3-diyl dicarbamate; 2-Phenyl-1,3-propanediol dicarbamate; Felbamyl
• Target: NMDA Receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)
• InChIKey: WKGXYQFOCVYPAC-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(COC(=O)N)COC(=O)N

Felbamate is an anti-epileptic drug used in the treatment of epilepsy. Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptors, the relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.

Reference

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