For research use only. Not for therapeutic Use.
FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception[1].
| Catalog Number | I027368 |
| CAS Number | 1374760-95-8 |
| Synonyms | 2-(4-methylphenoxy)-N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)acetamide |
| Molecular Formula | C17H17N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H17N3O2S/c1-13-4-6-14(7-5-13)22-12-17(21)20(16-8-9-18-19-16)11-15-3-2-10-23-15/h2-10H,11-12H2,1H3,(H,18,19) |
| InChIKey | QGDQESUNCJQMSA-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)OCC(=O)N(CC2=CC=CS2)C3=CC=NN3 |
| Reference | [1]. Alain Noncovich, et al. Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3931-3938. |
