FEN1-IN-4

• CAT Number: I015188
• CAS Number: 1995893-58-7
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.24
• Purity: ≥95%
• Target: FLAP

FEN1-IN-4 (CAT: I015188), also referred to as Compound 2, stands as a notable inhibitor of human flap endonuclease-1 (hFEN1). Flap endonuclease-1 plays a crucial role in DNA replication and repair by cleaving the RNA-DNA flap structures that arise during these processes. FEN1-IN-4’s inhibition of hFEN1 suggests its potential significance in the modulation of DNA repair mechanisms.

Reference

[1]. Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12(10):815-21.