Fenebrutinib HCl

For research use only. Not for therapeutic Use.

  • CAT Number: I027390
  • CAS Number: 2128304-54-9
  • Molecular Formula: C37H45ClN8O4
  • Molecular Weight: 701.27
  • Purity: 98%
Inquiry Now

Fenebrutinib HCl(Cat No.:I027390)is a selective inhibitor of Bruton’s tyrosine kinase (BTK), an enzyme critical to the activation of B-cells and the immune response. By inhibiting BTK, fenebrutinib blocks signaling pathways involved in autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis, as well as certain B-cell malignancies like chronic lymphocytic leukemia (CLL). Fenebrutinib HCl has shown promise in clinical trials for treating these conditions by modulating immune responses and reducing inflammation. Its targeted action on BTK offers potential advantages in treating autoimmune disorders and hematologic cancers with fewer side effects compared to traditional therapies.


Catalog Number I027390
CAS Number 2128304-54-9
Synonyms

GDC-0853; GDC 0853; GDC0853; RG-7845; RG7845; RG 7845; Fenebrutinib HCl; Fenebrutinib hydrochloride

Molecular Formula C37H45ClN8O4
Purity 98%
Solubility Soluble in DMSO
Appearance White to off-white solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 10-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl]amino]-6-oxopyridin-3-yl]pyridin-2-yl]-4,4-dimethyl-1,10-diazatricyclo[6.4.0.02,6]dodeca-2(6),7-dien-9-one;hydrochloride
InChI InChI=1S/C37H44N8O4.ClH/c1-23-18-42(27-21-49-22-27)9-10-43(23)26-5-6-33(39-17-26)40-30-13-25(19-41(4)35(30)47)28-7-8-38-34(29(28)20-46)45-12-11-44-31(36(45)48)14-24-15-37(2,3)16-32(24)44;/h5-8,13-14,17,19,23,27,46H,9-12,15-16,18,20-22H2,1-4H3,(H,39,40);1H/t23-;/m0./s1
InChIKey UFNQEETXQCTBNF-BQAIUKQQSA-N
SMILES C[C@H]1CN(CCN1C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=NC=C4)N5CCN6C7=C(CC(C7)(C)C)C=C6C5=O)CO)C8COC8.Cl

Request a Quote