For research use only. Not for therapeutic Use.
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM).
| Catalog Number | I045108 |
| CAS Number | 2166320-76-7 |
| Synonyms | N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-1-[[4-[(5-fluoro-2-oxopyridin-1-yl)methyl]phenyl]methyl]-3-(methoxymethyl)pyrazole-4-carboxamide |
| Molecular Formula | C26H25F2N5O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H25F2N5O4/c1-36-16-22-20(26(35)30-11-21-25(28)23(37-2)9-10-29-21)15-33(31-22)13-18-5-3-17(4-6-18)12-32-14-19(27)7-8-24(32)34/h3-10,14-15H,11-13,16H2,1-2H3,(H,30,35) |
| InChIKey | ZRUFVDPYHLTYPD-UHFFFAOYSA-N |
| SMILES | COCC1=NN(C=C1C(=O)NCC2=NC=CC(=C2F)OC)CC3=CC=C(C=C3)CN4C=C(C=CC4=O)F |
| Reference | [1]. Rebecca Louise DAVIE, et al. Pyrazole derivatives as plasma kallikrein inhibitors. WO2017207983A1. |
