Ferroptosis-IN-6

• CAT Number: I040148
• CAS Number: 1517780-59-4
• Molecular Formula: C15H17NO
• Molecular Weight: 227.30
• Purity: ≥95%
• Synonyms: 2-methyl-6-[(4-methylphenyl)methylamino]phenol
• InChI: InChI=1S/C15H17NO/c1-11-6-8-13(9-7-11)10-16-14-5-3-4-12(2)15(14)17/h3-9,16-17H,10H2,1-2H3
• InChIKey: DPIILYUBOSNTOP-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)CNC2=CC=CC(=C2O)C

Ferroptosis-IN-6 (compound 13) is a potent inhibitor of Ferroptosis with EC50 of 25.5 nM. Ferroptosis-IN-6 significantly inhibits RSL3-induced cell death in cells and in vivo[1].

Reference

[1]. Sheng XH, et al. Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities. Eur J Med Chem. 2023 Nov 28;264:115997.
 [Content Brief]