Ferroptosis-IN-6

• CAT Number: I040148
• CAS Number: 1517780-59-4
• Molecular Formula: C15H17NO
• Molecular Weight: 227.30
• Purity: ≥95%
• Synonyms: 2-methyl-6-[(4-methylphenyl)methylamino]phenol
• InChI: InChI=1S/C15H17NO/c1-11-6-8-13(9-7-11)10-16-14-5-3-4-12(2)15(14)17/h3-9,16-17H,10H2,1-2H3
• InChIKey: DPIILYUBOSNTOP-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)CNC2=CC=CC(=C2O)C

Ferroptosis-IN-6 (Cat No.: I040148) is a small-molecule inhibitor that targets ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxidation. By inhibiting key enzymes or pathways involved in ferroptosis, such as GPX4 (glutathione peroxidase 4), Ferroptosis-IN-6 helps protect cells from oxidative damage and iron toxicity. This makes it a promising therapeutic strategy for conditions like neurodegenerative diseases, ischemia-reperfusion injury, and cancer, where ferroptosis contributes to tissue damage or disease progression. Its selective action offers potential for reducing unwanted cell death.

Reference

[1]. Sheng XH, et al. Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities. Eur J Med Chem. 2023 Nov 28;264:115997.
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