For research use only. Not for therapeutic Use.
Ferroquine（Cat No.:R030221）, a derivative of chloroquine, is an antimalarial drug that incorporates a ferrocene moiety to enhance efficacy against drug-resistant malaria strains. This modification allows ferroquine to overcome resistance mechanisms that hinder conventional chloroquine action, making it a promising option in malaria-endemic regions. It disrupts parasite metabolism within red blood cells, specifically targeting heme detoxification pathways critical for parasite survival. With a favorable safety profile and potential to combat multi-drug-resistant Plasmodium strains, ferroquine is under investigation as a key candidate for advanced malaria therapies and combination treatments in resistant malaria management.
| Catalog Number | R030221 |
| CAS Number | 185055-67-8 |
| Synonyms | 7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline; Ferrochloroquine; SSR 97193 |
| Molecular Formula | C₂₃H₂₄ClFeN₃ |
| Purity | ≥95% |
| Target | hemozoin inhibitor |
| Storage | -20°C |
| Reference | </br>1:A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study. McCarthy JS, Rückle T, Djeriou E, Cantalloube C, Ter-Minassian D, Baker M, O/’Rourke P, Griffin P, Marquart L, Hooft van Huijsduijnen R, Möhrle JJ.Malar J. 2016 Sep 13;15:469. doi: 10.1186/s12936-016-1511-3. PMID: 27624471 Free PMC Article</br>2:Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents. Jacobs L, de Kock C, de Villiers KA, Smith PJ, Smith VJ, van Otterlo WA, Blackie MA.ChemMedChem. 2015 Dec;10(12):2099-110. doi: 10.1002/cmdc.201500349. Epub 2015 Oct 8. PMID: 26447782 </br>3:Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study. Held J, Supan C, Salazar CL, Tinto H, Bonkian LN, Nahum A, Moulero B, Sié A, Coulibaly B, Sirima SB, Siribie M, Otsyula N, Otieno L, Abdallah AM, Kimutai R, Bouyou-Akotet M, Kombila M, Koiwai K, Cantalloube C, Din-Bell C, Djeriou E, Waitumbi J, Mordmüller B, Ter-Minassian D, Lell B, Kremsner PG.Lancet Infect Dis. 2015 Dec;15(12):1409-19. doi: 10.1016/S1473-3099(15)00079-1. Epub 2015 Sep 3. PMID: 26342427 </br>4:Ferroquine: welcome to the next generation of antimalarials. Wells TN, Hooft van Huijsduijnen R.Lancet Infect Dis. 2015 Dec;15(12):1365-6. doi: 10.1016/S1473-3099(15)00148-6. Epub 2015 Sep 3. No abstract available. PMID: 26342426 </br>5:Ferroquine and its derivatives: new generation of antimalarial agents. Wani WA, Jameel E, Baig U, Mumtazuddin S, Hun LT.Eur J Med Chem. 2015 Aug 28;101:534-51. doi: 10.1016/j.ejmech.2015.07.009. Epub 2015 Jul 8. Review. PMID: 26188909 </br>6:In vitro and in vivo antischistosomal activity of ferroquine derivatives. Keiser J, Vargas M, Rubbiani R, Gasser G, Biot C.Parasit Vectors. 2014 Sep 4;7:424. doi: 10.1186/1756-3305-7-424. PMID: 25190030 Free PMC Article</br>7:Ferroquine as an oxidative shock antimalarial. Dive D, Biot C.Curr Top Med Chem. 2014;14(14):1684-92. PMID: 25116581 </br>8:The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition. Dubar F, Slomianny C, Khalife J, Dive D, Kalamou H, Guérardel Y, Grellier P, Biot C.Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7690-3. doi: 10.1002/anie.201303690. Epub 2013 Jun 13. PMID: 23765846 </br>9:The antimalarial ferroquine is an inhibitor of hepatitis C virus. Vausselin T, Calland N, Belouzard S, Descamps V, Douam F, Helle F, François C, Lavillette D, Duverlie G, Wahid A, Fénéant L, Cocquerel L, Guérardel Y, Wychowski C, Biot C, Dubuisson J.Hepatology. 2013 Jul;58(1):86-97. doi: 10.1002/hep.26273. Epub 2013 May 14. PMID: 23348596 </br>10:Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms. Salas PF, Herrmann C, Cawthray JF, Nimphius C, Kenkel A, Chen J, de Kock C, Smith PJ, Patrick BO, Adam MJ, Orvig C.J Med Chem. 2013 Feb 28;56(4):1596-613. doi: 10.1021/jm301422h. Epub 2013 Feb 14. PMID: 23327489 |
