For research use only. Not for therapeutic Use.
Fexofenadine is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria. Fexofenadine is classified as a second-generation antihistamine because it is less able to pass the blood-brain barrier and cause sedation, compared to a first-generation antihistamines.
| Catalog Number | R001766 |
| CAS Number | 83799-24-0 |
| Synonyms | 4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-benzene-acetic Acid; 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-?dimethylphenylacetic Acid; Carboxyterfenadine; MDL 16455; Terfenadine Acid Metabolite |
| Molecular Formula | C32H39NO4 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid |
| InChI | InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36) |
| InChIKey | RWTNPBWLLIMQHL-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O |
| Reference | </br>1:Fexofenadine, a putative in vivo P-glycoprotein probe, fails to predict clearance of the substrate tacrolimus in renal recipients. Vanhove T, Bouillon T, de Loor H, Annaert P, Kuypers DRJ.Clin Pharmacol Ther. 2017 Apr 24. doi: 10.1002/cpt.718. [Epub ahead of print] PMID: 28437851 </br>2:Effect of Garlic, Gingko, and St. John/’s Wort Extracts on the Pharmacokinetics of Fexofenadine: A Mechanistic Study. Turkanovic J, Ward MB, Gerber JP, Milne RW.Drug Metab Dispos. 2017 May;45(5):569-575. doi: 10.1124/dmd.116.073528. Epub 2017 Feb 10. PMID: 28188296 </br>3:Capsaicin pretreatment enhanced the bioavailability of fexofenadine in rats by P-glycoprotein modulation: in vitro, in situ and in vivo evaluation. Bedada SK, Appani R, Boga PK.Drug Dev Ind Pharm. 2017 Jun;43(6):932-938. doi: 10.1080/03639045.2017.1285310. Epub 2017 Feb 5. PMID: 28102715 </br>4:Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers. Li F, Howard KD, Myers MJ.J Pharm Pharmacol. 2017 Mar;69(3):274-284. doi: 10.1111/jphp.12687. Epub 2017 Jan 16. PMID: 28090646 </br>5:Comparison of efficacy, safety, and cost-effectiveness of montelukast-levocetirizine and montelukast-fexofenadine in patients of allergic rhinitis: A randomized, double-blind clinical trial. Mahatme MS, Dakhale GN, Tadke K, Hiware SK, Dudhgaonkar SD, Wankhede S.Indian J Pharmacol. 2016 Nov-Dec;48(6):649-653. doi: 10.4103/0253-7613.194854. PMID: 28066101 Free PMC Article</br>6:The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers. Bedada SK, Boga PK.Eur J Clin Pharmacol. 2017 Mar;73(3):343-349. doi: 10.1007/s00228-016-2173-3. Epub 2016 Dec 15. PMID: 27981349 </br>7:Investigating Drug Repositioning Approach to Design Novel Prodrugs for Colon-Specific Release of Fexofenadine for Ulcerative Colitis. Dhaneshwar SS, Singh P.Curr Drug Deliv. 2016 Dec 5. [Epub ahead of print] PMID: 27919212 </br>8:Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H<sub>1</sub> receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Kordulewska NK, Kostyra E, Cieślińska A, Matysiewicz M, Fiedorowicz E, Sienkiewicz-Szłapka E.Immunobiology. 2017 Mar;222(3):571-581. doi: 10.1016/j.imbio.2016.11.004. Epub 2016 Nov 10. PMID: 27843000 </br>9:Cytokine production by PBMC and serum from allergic and non-allergic subjects following in vitro histamine stimulation to test fexofenadine and osthole anti-allergic properties. Kordulewska NK, Kostyra E, Cieślińska A, Fiedorowicz E, Jarmołowska B.Eur J Pharmacol. 2016 Nov 15;791:763-772. doi: 10.1016/j.ejphar.2016.10.020. Epub 2016 Oct 15. PMID: 27756601 </br>10:Design, characterization and in vitro evaluation of HPMC K100 M CR loaded Fexofenadine HCl microspheres. Arefin P, Hasan I, Reza MS.Springerplus. 2016 May 25;5(1):691. doi: 10.1186/s40064-016-2322-2. eCollection 2016. PMID: 27350925 Free PMC Article |
