Fezolinetant HCl

• CAT Number: I048012
• CAS Number: 929016-98-8
• Molecular Formula: C20H31ClN4O2
• Molecular Weight: 394.9
• Purity: 98%
• Synonyms: Pracinostat Dihydrochloride
• Target: NK3
• Target Protein: RCLMPSZFYQJPQD-VHPXAQPISA-N
• Appearance: Solid
• IUPAC Name: (E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide;hydrochloride
• InChI: InChI=1S/C20H30N4O2.ClH/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3;/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25);1H/b12-10+
• SMILES: CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO.Cl

Fezolinetant hydrochloride (CAS 929016-98-8) is a selective and non-hormonal antagonist of the neurokinin-3 receptor (NK3R) currently under investigation for the treatment of menopausal symptoms. As a non-hormonal option, Fezolinetant HCl targets the neurokinin pathway, specifically blocking the action of neurokinin B. This mechanism is believed to mitigate the frequency and severity of hot flashes associated with menopause.