FFENM

• CAT Number: I027445
• CAS Number: 1639210-26-6
• Molecular Formula: C12H20FN
• Molecular Weight: 197.2974
• Purity: 98%
• Synonyms: FFENM; Fluoroethylnormemantine
• Target: Neuronal Signaling
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1s,3r,5R,7S)-3-(2-fluoroethyl)adamantan-1-amine
• InChI: InChI=1S/C12H20FN/c13-2-1-11-4-9-3-10(5-11)7-12(14,6-9)8-11/h9-10H,1-8,14H2/t9-,10+,11-,12-
• InChIKey: HUYVZSFADWYSHD-CDECOKDKSA-N
• SMILES: N[C@@]12C[C@@H]3C[C@H](C2)C[C@@](C1)(CCF)C3

FFENM is a novel potent neuroprotective agent for treatment of Alzheimer's disease (AD), targeting NMDA receptor.

Reference

1: Chen BK, Luna VM, Shannon ME, Hunsberger HC, Mastrodonato A, Stackmann M, McGowan JC, Rubinstenn G, Denny CA. Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior. Biol Psychiatry. 2021 May 9:S0006-3223(21)01298-1. doi: 10.1016/j.biopsych.2021.04.024. Epub ahead of print. PMID: 34274107.
2: Chen BK, Le Pen G, Eckmier A, Rubinstenn G, Jay TM, Denny CA. Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits. Int J Neuropsychopharmacol. 2021 Jul 14;24(6):519-531. doi: 10.1093/ijnp/pyab007. PMID: 33631001; PMCID: PMC8278800.
3: Couly S, Denus M, Bouchet M, Rubinstenn G, Maurice T. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer’s Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157. doi: 10.1093/ijnp/pyaa075. PMID: 32977336; PMCID: PMC7883897.
4: Salabert AS, Mora-Ramirez E, Beaurain M, Alonso M, Fontan C, Tahar HB, Boizeau ML, Tafani M, Bardiès M, Payoux P. Evaluation of [18F]FNM biodistribution and dosimetry based on whole-body PET imaging of rats. Nucl Med Biol. 2018 Apr;59:1-8. doi: 10.1016/j.nucmedbio.2017.12.003. Epub 2017 Dec 21. PMID: 29413751.
5: Salabert AS, Fonta C, Fontan C, Adel D, Alonso M, Pestourie C, Belhadj-Tahar H, Tafani M, Payoux P. Radiolabeling of [18F]-fluoroethylnormemantine and initial in vivo evaluation of this innovative PET tracer for imaging the PCP sites of NMDA receptors. Nucl Med Biol. 2015 Aug;42(8):643-53. doi: 10.1016/j.nucmedbio.2015.04.001. Epub 2015 Apr 7. PMID: 25963911.