FGFR2-IN-1

• CAT Number: I044158
• CAS Number: 2677709-76-9
• Molecular Formula: C22H19N3O2
• Molecular Weight: 357.41
• Purity: ≥95%
• Synonyms: N-[6-(3-ethoxyphenyl)-1H-indazol-3-yl]benzamide
• InChI: InChI=1S/C22H19N3O2/c1-2-27-18-10-6-9-16(13-18)17-11-12-19-20(14-17)24-25-21(19)23-22(26)15-7-4-3-5-8-15/h3-14H,2H2,1H3,(H2,23,24,25,26)
• InChIKey: QKJLYUUEYRTLCL-UHFFFAOYSA-N
• SMILES: CCOC1=CC=CC(=C1)C2=CC3=C(C=C2)C(=NN3)NC(=O)C4=CC=CC=C4

FGFR2-IN-1 is a selective FGFR2 inhibitor with an IC50 of 140 nM.

Reference

[1]. Turner LD, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J. Med. Chem. 2021 Nov 15.