FGFR2-IN-2

• CAT Number: I044157
• CAS Number: 2677709-81-6
• Molecular Formula: C23H22N4O
• Molecular Weight: 370.45
• Purity: ≥95%
• Synonyms: 4-[3-(4-piperazin-1-ylphenyl)-1H-indazol-6-yl]phenol
• InChI: InChI=1S/C23H22N4O/c28-20-8-3-16(4-9-20)18-5-10-21-22(15-18)25-26-23(21)17-1-6-19(7-2-17)27-13-11-24-12-14-27/h1-10,15,24,28H,11-14H2,(H,25,26)
• InChIKey: OYKIIJTXTXJYKZ-UHFFFAOYSA-N
• SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=NNC4=C3C=CC(=C4)C5=CC=C(C=C5)O

FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively[1].

Reference

[1]. Lewis D Turner, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J Med Chem. 2022 Jan 27;65(2):1481-1504.
 [Content Brief]