For research use only. Not for therapeutic Use.
FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].
FGFR3-IN-5 (compound 37; 5 mM; 1 h; HEK-293 cells) inhibits FGFR phosphorylation with IC50 values of 8 and 59 nM for FGFR3 and FGFR1, respectively[1].
| Catalog Number | I041972 |
| CAS Number | 2446664-72-6 |
| Synonyms | 6-[1-[1-(3-fluoro-1-prop-2-enoylazetidine-3-carbonyl)piperidin-4-yl]pyrazol-4-yl]-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile |
| Molecular Formula | C24H24FN7O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H24FN7O3/c1-3-21(33)30-14-24(25,15-30)23(34)29-6-4-19(5-7-29)31-13-18(11-27-31)16-8-20(35-2)22-17(9-26)10-28-32(22)12-16/h3,8,10-13,19H,1,4-7,14-15H2,2H3 |
| InChIKey | GUEZCEZQFMVREH-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CN2C1=C(C=N2)C#N)C3=CN(N=C3)C4CCN(CC4)C(=O)C5(CN(C5)C(=O)C=C)F |
| Reference | [1]. James FB, et, al. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases. WO2020131627. |
