For research use only. Not for therapeutic Use.
FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.
FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC50 of 7.8 nM[1].
| Catalog Number | I002232 |
| CAS Number | 1708971-72-5 |
| Synonyms | N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(3-oxomorpholin-4-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide |
| Molecular Formula | C24H27N7O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H27N7O5/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34) |
| InChIKey | ZTYSXMGILYNNJX-UHFFFAOYSA-N |
| SMILES | COCCNC1=CC(=NC=C1C#N)NC(=O)N2CCCC3=CC(=C(N=C32)C=O)CN4CCOCC4=O |
| Reference | [1]. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668 A1? |
