For research use only. Not for therapeutic Use.
ALK2-IN-1 is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1, Compound 876, has an IC50 of <10 nM[1].
| Catalog Number | I023484 |
| CAS Number | 2141955-96-4 |
| Synonyms | [(3R)-oxolan-3-yl] 4-[6-[5-(4-ethoxy-1-propan-2-ylpiperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazine-1-carboxylate |
| Molecular Formula | C31H42N6O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C31H42N6O4/c1-4-40-31(9-12-34(13-10-31)23(2)3)25-5-6-27(32-20-25)24-19-29-28(7-11-33-37(29)21-24)35-14-16-36(17-15-35)30(38)41-26-8-18-39-22-26/h5-7,11,19-21,23,26H,4,8-10,12-18,22H2,1-3H3/t26-/m1/s1 |
| InChIKey | SWVYYNLRVIYURK-AREMUKBSSA-N |
| SMILES | CCOC1(CCN(CC1)C(C)C)C2=CN=C(C=C2)C3=CN4C(=C3)C(=CC=N4)N5CCN(CC5)C(=O)OC6CCOC6 |
| Reference | [1]. Natasja Brooijmans, et al. Inhibitors of activin receptor-like kinase. WO2017181117A1. |
