For research use only. Not for therapeutic Use.
FIN56 (Cat.No:I006794)is a small molecule that has gained attention for its ability to target and inhibit the enzyme IMPDH (inosine-5′-monophosphate dehydrogenase), which is crucial for guanine nucleotide biosynthesis. By disrupting this pathway, FIN56 has shown potential in inducing selective cell death in cancer cells, particularly those with high metabolic demands. It is also being studied for its ability to sensitize tumor cells to other therapies. Research continues into its effectiveness and safety as a potential anticancer agent.
| Catalog Number | I006794 |
| CAS Number | 1083162-61-1 |
| Synonyms | FIN56; FIN-56; FIN 56.;N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide |
| Molecular Formula | C25H31N3O5S2 |
| Purity | ≥95% |
| Target | Ferroptosis |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 2-N,7-N-dicyclohexyl-9-hydroxyiminofluorene-2,7-disulfonamide |
| InChI | InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2 |
| InChIKey | JLCFMMIWBSZOIS-UHFFFAOYSA-N |
| SMILES | O=S(C1=CC(/C2=NO)=C(C3=C2C=C(S(=O)(NC4CCCCC4)=O)C=C3)C=C1)(NC5CCCCC5)=O |
| Reference | 1:Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503. doi: 10.1038/nchembio.2079. Epub 2016 May 9. PubMed PMID: 27159577; PubMed Central PMCID: PMC4920070. |
