For research use only. Not for therapeutic Use.
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1].
FINO2 (10 µM; 24 h) induce ferroptosis and shows iron dependence of lipid peroxidation in HT-1080 cells[1].
| Catalog Number | I027482 |
| CAS Number | 869298-31-7 |
| Synonyms | 2-(8-tert-butyl-3-methyl-1,2-dioxaspiro[4.5]decan-3-yl)ethanol |
| Molecular Formula | C15H28O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H28O3/c1-13(2,3)12-5-7-15(8-6-12)11-14(4,9-10-16)17-18-15/h12,16H,5-11H2,1-4H3 |
| InChIKey | RWJLCLCUNHUSPG-UHFFFAOYSA-N |
| SMILES | CC1(CC2(CCC(CC2)C(C)(C)C)OO1)CCO |
| Reference | [1]. Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515. |
