For research use only. Not for therapeutic Use.
Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection[1][2].
Fipexide (50 μM; for 15 days) shows simple structures, which contained epidermal regions with well-expanded cells and actively dividing regions for Arabidopsis wild-type seedlings[2]
Fipexide (10 mg/kg; orally; 5-10 days) completely abolishes the memory deficit produced by kindling in rats[3]
Catalog Number | I003239 |
CAS Number | 34161-24-5 |
Synonyms | 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanone |
Molecular Formula | C20H21ClN2O4 |
Purity | ≥95% |
InChI | InChI=1S/C20H21ClN2O4/c21-16-2-4-17(5-3-16)25-13-20(24)23-9-7-22(8-10-23)12-15-1-6-18-19(11-15)27-14-26-18/h1-6,11H,7-10,12-14H2 |
InChIKey | BFUJHVVEMMWLHC-UHFFFAOYSA-N |
SMILES | C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C(=O)COC4=CC=C(C=C4)Cl |
Reference | [1]. A Marino, et al. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol Res. Mar-Apr 1990;22(2):179-87. [2]. Takeshi Nakano, et al.FPX is a Novel Chemical Inducer that Promotes Callus Formation and Shoot Regeneration in Plants. Plant Cell Physiol. 2018 Aug 1;59(8):1555-1567. [3]. M G Genkova-Papazova, et al. Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats. Eur Neuropsychopharmacol. 1996 Nov;6(4):285-90. |