For research use only. Not for therapeutic Use.
FIPI（Cat No.:I005579）is a potent inhibitor of phospholipase D (PLD), an enzyme involved in the regulation of lipid signaling pathways that affect various cellular processes, including membrane trafficking, cell migration, and survival. By inhibiting PLD, FIPI alters the production of phosphatidic acid, a key signaling lipid, thus modulating cellular responses. FIPI is widely used in research to study the role of PLD in cancer, neurodegenerative diseases, and immune responses. Its ability to selectively inhibit PLD makes it a valuable tool for exploring therapeutic strategies that target lipid signaling pathways.
| Catalog Number | I005579 |
| CAS Number | 939055-18-2 |
| Synonyms | (Z)-5-fluoro-N-(2-(4-(2-hydroxy-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carbimidic acid |
| Molecular Formula | C23H24FN5O2 |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | DMSO: ≤ 14.67 mg/mL |
| Storage | Store at 4℃ |
| IC50 | 20 nM (PLD2) |
| IUPAC Name | 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide |
| InChI | InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31) |
| InChIKey | LHABRXRGDLASIH-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F |
| Reference | </br>1:Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N/’-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL.Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12. PMID: 21994240 Free PMC Article</br>2:5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Su W, Yeku O, Olepu S, Genna A, Park JS, Ren H, Du G, Gelb MH, Morris AJ, Frohman MA.Mol Pharmacol. 2009 Mar;75(3):437-46. doi: 10.1124/mol.108.053298. Epub 2008 Dec 8. PMID: 19064628 Free PMC Article |
