FITC-labeled ODN 1018 sodium

• CAT Number: I041001
• Molecular Weight: 8171.00
• Purity: ≥95%

FITC-labeled ODN 1018 sodium (Cat No.: I041001) is a fluorescently tagged CpG oligodeoxynucleotide, designed to activate Toll-like receptor 9 (TLR9) and stimulate immune cell activation, particularly in B cells and monocytes. As a Class B CpG ODN, ODN 1018 induces strong pro-inflammatory cytokine responses and is widely used in vaccine adjuvant research. The FITC label enables real-time tracking of cellular uptake and localization through fluorescence-based techniques. Provided as a sodium salt, it is for research use only in immunology and vaccine studies.

Reference

[1]. Eng NF, et al. The potential of 1018 ISS adjuvant in hepatitis B vaccines: HEPLISAV™ review. Hum Vaccin Immunother. 2013 Aug;9(8):1661-72.
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[2]. Friedberg JW, et al. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009 Aug;146(3):282-91.
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