For research use only. Not for therapeutic Use.
FITC-labeled ODN 2216 sodium (Cat No.: I041000) is a fluorescein-conjugated synthetic oligodeoxynucleotide that contains unmethylated CpG motifs, designed to activate Toll-like receptor 9 (TLR9). This Class A CpG ODN is widely used in immunology research to stimulate plasmacytoid dendritic cells (pDCs) and induce robust type I interferon responses. The FITC label enables visualization and tracking in cellular uptake and binding assays via fluorescence microscopy or flow cytometry. Supplied as a sodium salt, it is intended for research use only in immune activation studies.
Purity | ≥95% |
Reference | [1]. He Y, et al. Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice. Hepatology. 2017 Jul;66(1):220-234. [2]. Huang L, et al. CpG-based immunotherapy impairs antitumor activity of BRAF inhibitors in a B-cell-dependent manner. Oncogene. 2017 Jul 13;36(28):4081-4086. [3]. Krug A, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol. 2001 Jul;31(7):2154-63. [4]. Li Y, et al. A novel antagonist of TLR9 blocking all classes of immunostimulatory CpG-ODNs. Vaccine. 2011 Mar 3;29(11):2193-8. [5]. Okada T, et al. Murine thymic plasmacytoid dendritic cells. Eur J Immunol. 2003 Apr;33(4):1012-9. |
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