For research use only. Not for therapeutic Use.
FJ9 (Cat No.: I027489) is a small-molecule inhibitor that disrupts the interaction between the E3 ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) and its associated chaperone proteins. By targeting this protein-protein interaction, FJ9 modulates protein quality control and degradation pathways, which are crucial in maintaining cellular homeostasis. It has shown potential in studies related to neurodegenerative diseases and cancer, where dysregulated protein folding and degradation contribute to pathology. FJ9 serves as a valuable tool in probing the ubiquitin-proteasome system and chaperone-mediated cellular processes.
| Synonyms | FJ-9; FJ 9; FJ9 |
| Molecular Formula | C23H27NO3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-(1-Hydroxypentyl)-6-methyl-3-phenethyl-1H-indole-5-carboxylic acid |
| InChI | InChI=1S/C23H27NO3/c1-3-4-10-21(25)22-17(12-11-16-8-6-5-7-9-16)19-14-18(23(26)27)15(2)13-20(19)24-22/h5-9,13-14,21,24-25H,3-4,10-12H2,1-2H3,(H,26,27) |
| InChIKey | CTHUKURTASAUTM-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC2=C(NC(C(O)CCCC)=C2CCC3=CC=CC=C3)C=C1C)O |
| Reference | 1: Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One. 2016 May 23;11(5):e0156111. doi: 10.1371/journal.pone.0156111. eCollection 2016. PubMed PMID: 27214381; PubMed Central PMCID: PMC4877088. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
