For research use only. Not for therapeutic Use.
FJ9 is a FZD7 inhibitor which disrupts protein-protein interaction between Frz7 and the PDZ domain of DVL, and induces apoptosis in melanoma cell line and non-small cell lung cancer cell line.
| Catalog Number | I027489 |
| Synonyms | FJ-9; FJ 9; FJ9 |
| Molecular Formula | C23H27NO3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-(1-Hydroxypentyl)-6-methyl-3-phenethyl-1H-indole-5-carboxylic acid |
| InChI | InChI=1S/C23H27NO3/c1-3-4-10-21(25)22-17(12-11-16-8-6-5-7-9-16)19-14-18(23(26)27)15(2)13-20(19)24-22/h5-9,13-14,21,24-25H,3-4,10-12H2,1-2H3,(H,26,27) |
| InChIKey | CTHUKURTASAUTM-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC2=C(NC(C(O)CCCC)=C2CCC3=CC=CC=C3)C=C1C)O |
| Reference | 1: Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One. 2016 May 23;11(5):e0156111. doi: 10.1371/journal.pone.0156111. eCollection 2016. PubMed PMID: 27214381; PubMed Central PMCID: PMC4877088. |
