FK 33-824

• CAT Number: I027498
• CAS Number: 64854-64-4
• Molecular Formula: C29H41N5O7S
• Molecular Weight: 603.73
• Purity: 98%
• Synonyms: FK 33-824; FK-33-824; FK33-824; SAN 33-824; Damme; Sandoz FK 33-824
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-[[(2S)-1-hydroxy-4-methylsulfinylbutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
• InChI: InChI=1S/C29H41N5O7S/c1-19(32-28(39)24(30)15-21-9-11-23(36)12-10-21)27(38)31-17-26(37)34(2)25(16-20-7-5-4-6-8-20)29(40)33-22(18-35)13-14-42(3)41/h4-12,19,22,24-25,35-36H,13-18,30H2,1-3H3,(H,31,38)(H,32,39)(H,33,40)/t19-,22+,24+,25+,42?/m1/s1
• InChIKey: HYZHONGSQNXMPH-IQNHEXCWSA-N
• SMILES: C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCS(=O)C)CO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N

FK 33-824（Cat No.:I027498）is a potent small molecule inhibitor of the protein kinase CK2 (casein kinase 2), an enzyme involved in regulating various cellular processes, including cell growth, survival, and apoptosis. CK2 is often overexpressed in several cancers and is linked to tumor progression. By inhibiting CK2, FK 33-824 shows promise in reducing tumor cell proliferation and enhancing the sensitivity of cancer cells to other treatments. Preclinical studies have indicated its potential in treating cancers like leukemia and breast cancer. However, further clinical trials are necessary to assess its safety, efficacy, and therapeutic applications.

Reference

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