For research use only. Not for therapeutic Use.
Highly specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); NAD biosysthesis inhibitor; Tumor cell apoptosis agent (see also Axon 1279)
| Catalog Number | I047544 |
| CAS Number | 2727965-45-7 |
| Molecular Formula | C24H29N3O2.HCl |
| Purity | ≥95% |
| IUPAC Name | (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-pyridin-3-ylprop-2-enamide;hydrochloride |
| InChI | InChI=1S/C24H29N3O2.ClH/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22;/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28);1H/b12-11+; |
| SMILES | C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3.Cl |
| Reference | M. Hasmann and I. Schemainda, FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 2003, 63, 7436-7442.
A Pogrebniak et al. Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. Eur. J. Med. Res. 2006, 11(8), 313-321.
K Holen et al. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest. New Drugs. 2008, 26(1), 45-51. |
